In one aspect, the invention relates to 0-benzyl nicotinamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5);synthetic methods for making the compounds;pharmaceutical compositions comprising the compounds;and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions.

In one aspect, the invention relates to 0-benzyl nicotinamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5)

The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmaceutical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and / or low dissolution rate pharmacuetical agents. The present invention is further directed to methods for manufacturing of said drug compositions and dosage forms. The prese...

The present invention provides a method for the treatment of psychiatric patients having or at risk of hepatic impairment comprising administering a therapeutically effective amount of paliperidone its pharmaceutically acceptable acid addition salts enantiomeric forms and esters thereof to psychiatric patients in need thereof.

A method for treating advanced epithelial ovarian cancer patients who attain a clinically-defined complete response after initial platinum/paclitaxel-based chemotherapy is described. The method involves administering a chemotherapeutic agent, such as doxorubicin, entrapped in liposomes.

A liposome composition comprised of liposomes having the peptide boronic acid proteasome inhibitor compound bortezomib entrapped in the liposomes is described. The boronic acid compound is entrapped in the liposomes in the form of a boronate ester, subsequent to interaction with a liposome-entrapped polyol. In one embodiment, the liposomes have an outer coating of hydrophilic polymer chains and are used to treat a solid tumor in a subject.

The invention relates to conjugates of anti-integrin specific antibodies with cytotoxic compounds, the synthesis, selection, and use of such conjugates for use in cancer therapy or other diseases mediated by cell proliferation, cell migration, or inflammation and which pathology involves angiogenesis or neovascularization of new tissue. In addition the invention relates to combination therapy of such diseases wherein the treatment comprises use of said conjugates in combination with one or more ...

A complex comprised of gabapentin or pregabalin and a transport moiety such as an alkyl sulfate is described. The complex has an enhanced absorption in the gastrointestinal tract particularly the lower gastrointestinal tract. The complex and compositions and dosage forms prepared using the complex provide for absorption by the body of the drug through a period of ten to twenty-four hours thus enabling a once-daily dosage form for gabapentin or pregabalin.

This invention relates to methods of treatments compositions and kits for providing rapid relief to the user for pruritic and neurogenic skin disorders by applying sertaconazole. The invention also provides methods of treatments compositions and kits for preventing such conditions.